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Description
In pre-clinical research, IGF-1 LR3 is often used to examine IGF-1 receptor interaction, extended signaling duration, and downstream pathway activation

10.1093/ajcn/nqaa177 59 SeligmanJ.NewtonG

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Zhao Y, Ray A, Portengen L et al (2023) Metal exposure and risk of Parkinson disease: a systematic review and meta-analysis

The application of IGF-1R inhibitor (picropodophyllin, 250 g/kg) prevented the induction of GRK2 and the regression of hyperalgesia after plantar incision, indicating that the induction of GRK2 expression driven by tissue IGF-1 has an effective analgesic effect[69]