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How This Works When skeletal muscle is loaded or damaged, the IGF-1 gene is alternatively spliced and the MGF (IGF-1Ec) mRNA is transiently up-regulated first, correlating with markers of satellite-cell activation, before a later switch toward systemic IGF-1Ea associated with differentiation and repair [2]

Important for muscle growth and maintenance*

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CA2 KOR and DOR activation in CA2 increases the PS following stratum radiatum stimulation (Vidal et al., 1984)

However, another research found that women with FMS and low IGF-1 levels improved their overall symptoms and number of pain points after receiving daily growth hormone therapy for 9 months, indicating that increased IGF-1 level in serum can relieve FMS[94]

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