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It is potentially harmful

doi: 10.1016/j.wneu.2012.11.062

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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

Tier 1 protocols may range from $300-600 monthly, Tier 2 from $500-1,200 monthly, and Tier 3 from $800-2,000 monthly depending on complexity