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Nat Rev Drug Discov 5:493506

Drugs that are completely retained within the vascular compartment, on the other hand, would have a minimum possible volume of distribution equal to the blood component in which they are distributed, eg, 0.04 L/kg body weight or 2.8 L/70 kg ( Table 32 ) for a drug that is restricted to the plasma compartment

728 Conditional knockout of FPN1 in mouse endothelial cells (ECs) reduces the level of iron in the brain, oxidative stress, and ferroptosis after stroke, and finally reduces the volume of cerebral infarction and the nerve function injury in the acute stage of ischemic stroke

doi: 10.1038/s41366-022-01064-9 44 LongEKOlsonDMBernlohrDA

PMID: 36170435

J Am Chem Soc , 128 (33): 10784-94