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Possible neuroprotective effects of l-Carnitine on White-Matter microstructural damage and cognitive decline in Hemodialysis patients

TMAO reduces bile acid pools, inhibiting FXR activity, disrupting bile acid-FXR signaling, and upregulating pathways worsening hepatic steatosis, as confirmed in HFD-fed C57BL/6J mice and human samples (154)

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Figure 2

Fan JP, Kim HS, Han GD

BRPF1 contains a bromodomain, which is reported to bind H2AK5ac, H4K12ac, and H3K14ac (Poplawski et al, 2014), and two PHD fingers closely linked by a zinc knuckle, which bind to unmodified histone H3 tail and nucleosomal DNA (Klein et al, 2016)