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Acta Pharmacol Sin (2022) 43:194208

Explains how glutathione influences melanogenesis by shifting the balance from darker eumelanin to lighter pheomelanin via inhibition of tyrosinase (by copper chelation and antioxidant effect)

Fe 2+ reduces oxygen to form superoxide radicals, which cause lipid peroxidation through the Fenton reaction and induce ferroptosis in cells (15)

Also, some peopl have an autoimmune or inflammatory condition of the stomach wall that degrade the proteins that aid vitamin B12 absorption

doi:10.1351/goldbook.B00658 Spinal Cord Medicine

EBioMedicine 81:104082 Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM (2020) Complex interplay between autophagy and oxidative stress in the development of pulmonary disease