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Specifically, the following aspects are described: (i) description of ROS and RNS and antioxidant defenses, (ii) the importance of reduced glutathione (GSH) as an antioxidant agent, (iii) the participation of GSH in the prevention of cardiovascular diseases, (iv) the relationship between the production of reactive species and the development of cardiovascular diseases

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At the time of the papers publication, the proposed pathway still lacked definition at the enzymatic level

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