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This bidirectional gene modulation profile simultaneously promoting tissue remodeling while suppressing destructive inflammation is unusually broad for a tripeptide and distinguishes GHK-Cu from most single-target peptide ligands in the research literature

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This activation alleviates the damage to the alveolar capillary barrier and maintains the barrier function of pulmonary microvascular endothelial cells, suggesting that the SIRT1/p53 axis plays a crucial role in regulating ferroptosis in ALI (Lin et al., 2024b)

The Scientific Rationale for Using Stem Cell Secretome in COPD Treatment "COPD is driven by chronic inflammation and progressive lung tissue destruction