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APAP can be synthesized in the body through O-dealkylation of the prodrug phenacetin, a pain-killer that was withdrawn from the market due to nephrotoxicity and carcinogenesis [3]

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In an HIV-positive cohort, Blzquez-Bondia et al

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The research suggests that while muscles initially try to adapt by increasing glycolysis (burning glucose without oxygen), prolonged exposure to this diseased sera leads to muscle fragility, weakness, and eventual metabolic collapse
