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Mol Cell Biol, 2010

FEBS Lett 592(5):679

doi: 10.1016/s0006-8993(00)02637-8

The glutamate is then transported into the cell as gamma-glu-aa and is transformed into 5-oxoproline via gamma glutamyl cyclotransferase

GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss

Although mRNA vaccines (e.g., BNT162b2) partially mitigate age-related immune deficits by enhancing GC reactions and memory B cell generation, their protective efficacy against COVID-19 in older adults remains suboptimal