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These chronic diseases seldom exist discretely in older people, which makes it challenging for clinical strategies to treat specific diseases and resolve various symptoms resulting from comorbid conditions

Preclinical data has shown support for this mechanism of action, as niacin treatment in the rotenone model of PD increases brain dopamine levels, compared to vehicle controls [9]

doi: 10.1186/1471-2202-8-35, [DOI] [PMC free article] [PubMed] [Google Scholar] Laureys G., Valentino M., Demol F., Zammit C., Muscat R., Cambron M., et al

doi: 10.3389/fmicb.2023.1111911 76 RodriguesV

These include the regulation of inflammation, promotion of cell migration and fibroblast proliferation, stimulation of collagen synthesis, enhancement of angiogenesis, and remodeling of the ECM [24, 32-36, 58-60]