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Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinsons disease

Miller, et al

doi: 10.1177/0271678X17734100

293,294 YAP can inhibit glucose-6-phosphatase catalytic subunit (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1) via peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1), eventually hampering gluconeogenesis

Iron, which has long been recognized as a double-edged sword in biology, plays an indispensable role in central nervous system (CNS) functions and participates in multiple essential processes, such as oxygen transport, DNA synthesis, mitochondrial respiration, and neurotransmitter synthesis [12,13]

To describe these interactions more in detail, electron density analyses (Atoms in Molecules, AIM) [30], [31] were carried out on some geometrically selected structures at the B3LYP/6-31G (d) level of theory