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The role of different SIRT1-mediated signaling pathways in toxic injury

Leucoplasts synthesize and store carbohydrates, lipids, and proteins

38 Receptor-mediated and lipid-driven mitophagy pathways in the heart Beyond PINK1-Parkin, FUNDC1 has emerged as a key mitophagy regulator, particularly under hypoxia

It also increased the expression of energy expenditure-related genes such as UCP3, PGC1, and 3-Adr, contributing to body weight reduction in HFD-induced obese mice (Doan et al., 2015)

In addition, we also observed lower expression of BAX and caspase 3 and higher expression of Bcl-2 in hyperplastic prostate tissues compared with normal prostate tissues, which showed that with the down-regulation of GPX3, the apoptosis level of hyperplastic prostate was inhibited at the tissue level

This not only enhances their inflammatory potential but also affects antigen processing, glutathionylation of signaling proteins, and interactions with resident CNS cells such as microglia and astrocytes (Federici et al., 2024)