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Beberapa faktor yang menjadi penyebab kurangnya glutathione dalam tubuh, yaitu polusi udara, paparan zat beracun, infeksi, stress, paparan radikal bebas, serta faktor usia

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With concurrent downregulation of ferroportin (FPN) and iron-regulating proteins (IRP1/2), M1-polarized macrophages show increased hepcidin (Hamp) and ferritin heavy/light chains (FTH/FTL) relative to their M2 counterparts (96)

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Biochem Biophys Res Commun 2004, 319: 801809

During a secondary stimulus to induce relapse of corneal neovascularization, the degenerating blood vessels rapidly normalized via EC recovery, vasodilation, and perfusion with tightly packed erythrocytes, facilitating the relapse of corneal neovascularization