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Moraes found that ADSC-derived EVs may activate the Janus kinase (JAK)/signal transducer and activator of transcription (STAT-3) pathway through epidermal growth factor receptor 1 (EGFR-1)/IL-6, thereby promoting breast cancer cell migration and metastasis (Moraes et al

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However, significant limitations persist: foundational studies often rely on broad-spectrum antibiotic-induced microbiota depletion models or direct metabolite injection/gavage, poorly replicating the spatiotemporal heterogeneity and metabolic dynamics present within a natural gut microbiota network (Gheorghe et al., 2021

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