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Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma

Glutathione is a key player in Phase II detoxification
Loss of the Nrf2-ARE function in mice has been shown to increase susceptibility [98] to acute toxicity, inflammation, and carcinogenesis due to the inability to mount adaptive responses

After a closed head injury, ApoE / mice exhibit elevated levels of iron in their brains, suggesting that ApoE / deficiency may increase the risk of oxidative damage to hippocampal tissue ( In vitro studies show that upregulating sestrin2 decreases type I/II collagen and KEAP1 mRNA expression while increasing GPX4 and Nrf2 mRNA levels
Prior studies suggest that there is an association between stress from early adverse life events and the development of irritable bowel syndrome (IBS), a functional disorder associated with a higher intestinal permeability [93, 94]
Science 376 , eabl4290 (2022)
