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In most cases, they are loss-of-function mutations of KEAP1 or gain-of-function mutations of NRF2 , causing the persistent stabilization of NRF2

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For example, histamine can reduce pro-inflammatory cytokine production such as IL-1 in response to mediators such as LPS as well modulate overall microglial motility (Ferreira et al., 2012)

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In those with chronic excessive alcohol consumption, Wernicke encephalopathy and Korsakoff psychosis result mainly from thiamine deficiency