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These results suggest that DY is a promising medication for therapeutic management and a supplementary therapy for drug-resistant CRC.92 Dihydromyricetin, a flavonoid compound derived from Hovenia dulcis (Japanese raisin tree), suppressed the expression of MRP2 and its promoter activity by inhibiting the NF-B-Nrf2 signaling pathway in HCT-8/VCR and HCT116/L-OHP cells

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Biol Pharm Bull 38(5):694702 Garca-Galiano D, Snchez-Garrido MA, Espejo I, Montero JL, Costn G, Marchal T, Membrives A, Gallardo-Valverde JM, Muoz-Castaeda JR, Arvalo E, De la Mata M, Muntan J (2007) IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients