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methyl pyruvate (10mM,Figure 2) rescued cells with GDH inhibited [5,26], a significant fraction of the population succumbed associated with a reduced cell pH [26]

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doi: 10.1152/ajpendo.1997.273.6.E1107

Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations