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FIGURE 1 Glutathione peroxidase 4 inactivation or depletion induces ferroptosis Glutathione peroxidase 4 (GPX4) scavenges lipid peroxides to generate lipid alcohols, which inhibits Fe 2+ induced reactive oxygen species (ROS) production (Shyu et al., 2014

Thus, following flavin reduction, electrons either flow backwards, regenerating NADPH, or will move further into the enzyme reducing the disulfide pair most proximal to the N5 position of the isoalloxazine ring of the FAD, C154-C159 (Figure 2)

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Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

A Multicenter Phase 2 Trial (SAKK 15/12), International Journal of Radiation and Oncology in Biology and Physics 107 (2020): 279287