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Description
doi: 10.1161/HYPERTENSIONAHA.116.07910 183
Metall Mater Data
In vivo, its metabolites include trichloroacetic acid, proving that it functions as a substrate (Poon et al., 2000) there by being capable of inhibiting the metabolism of other aldehydic substrates of ALDHs
Importantly, clinical trials are now ongoing in which rhTrx1 is being administered to patients with atopic dermatitis and trans-tracheal inhalation experiment with rhTrx1 are being performed
doi: 10.1128/aem.00325-24 44 De VadderF.Kovatcheva-DatcharyP.GoncalvesD.VineraJ.ZitounC.DuchamptA.et al
Other examples for IN application of systemic acting small molecules are analgesics with anti-inflammatory effects such as indomethacin and ketorolac [14]
