glutathione myelin sheath repair Frontiers Central nervous system demyelinating diseases:

Neuroscience

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Sf9 cells expressing wild-type SRD5A2 (WT), and mutants E57Q and Y91F were harvested after 48 h transfection

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To lift the barrier, the cytosolic loops in SRD5A2 may undergo conformational changes during the reaction so that the cytosolic region can open up to expose the nucleotide-binding pocket to the cytosol before and after one reaction to allow NADP + /NADPH exchange, and thus efficient reaction turnover