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In addition, as seen in Supplementary Fig

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A promising new approach to cancer therapy: targeting iron metabolism in cancer stem cells

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While preclinical studies suggest that metformin enhances radiosensitivity and reduces tumor recurrence, its clinical application remains in early stages, with further studies needed to optimize dosing regimens and understand its full therapeutic potential

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Zhou K, Song Y, Zhou W, Zhang C, Shu H, Yang H, et al

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The above findings indicate that NETs in the tumor environment are crucial for tumor progression, and inhibiting the formation of NETs could significantly improve the efficacy of immunotherapy, radiation therapy, and chemotherapy

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