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2019 Apr 1;8(4):82

HNE reduces non-canonical inflammasome-mediated IL-1 release, but has no effect on GSDMD-mediated cell death Non-canonical inflammasome activation is dependent on caspase-11 (in mice) or caspase-4 (in humans) which directly bind with intracellular LPS (39, 40)

Compared to the placebo group, which did not exhibit any changes in baseline levels, the experimental group showed a substantial improvement in all parameters, including VO2 max, time to exhaustion on the treadmill, and METS (metabolic equivalents) (91)

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