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While many of these studies are based on animal models, early human trials and anecdotal reports suggest promising results

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In parallel, efforts are underway to identify early biomarkers, including those based on cerebrospinal fluid (CSF), peripheral blood, imaging modalities, and multi-omic signatures, to enable earlier intervention, before extensive neuronal loss has occurred

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This can be especially problematic in applications where maintaining drug potency and precise delivery timing is crucial, such as cancer therapy or treating infectious diseases