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Oncogene 18 : 61046111 Filomeni G, Aquilano K, Rotilio G and Ciriolo MR (2003) Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide

Numerous investigational therapies targeting inflammation, oxidative stress, liver regeneration, bile acid signalling, epigenetic regulation, and the gut-liver axis have been evaluated, with largely disappointing results

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This dual benefit is part of the rationale for filing CagriSema in both obesity and T2D contexts

The vector also includes a Zeocin resistance gene for selection, and the presence of an AOX1 promoter allows for the methanol-inducible expression of the inserted gene, offering control over the expression levels

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