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[DOI] [PMC free article] [PubMed] [Google Scholar] Chhonker Y

Flavonoids can protect cell membranes from oxidative stress by inhibiting lipid peroxidation [66]

While serum autoantibody levels against the immunodominant 16th non-collagenous domain (NC16A) of BP180 correlate with the disease activity of patients and various mouse models based on immunity against the murine homologue of BP180 NC16A have been established, the pathogenic relevance of anti-BP230 antibodies is less clear [69,70,71,72,73]

141 Notably, it has been reported that the first extracellular domains of claudin-2 and claudin-4 are a key determinant of paracellular charge selectivity and barrier function, but these domains are not involved in the formation of tight junction strands

In this investigation, we initially identified oridonin as a direct covalent inhibitor of GSH, setting it apart from other drugs that disrupt ROS by targeting proteins both upstream and downstream of GSH