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Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors

As stated above, especially mechanistic insights are missing, and in the case of diseases, this is even more evident

Addressing these challenges requires a multidisciplinary approach, incorporating advancements in vector design, immunomodulation, and manufacturing processes to ensure broad and sustained therapeutic efficacy

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