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Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial

This is critical

As the main methyl donor in cells, SAM also mediates a variety of methylation reactions, aside from DNA methylation, including histone, RNA, and some protein amino acid residue methylation (Teperino et al., 2010)

GluN2B NAMs also produce rapid antidepressant effects (see below), and comparing the effects of ketamine to GluN2B NAMs may help to provide such mechanistic insights

Gullett JM, Tweedell RE, Kanneganti TD

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