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Cortical disconnection due to myelin loss has been proposed as a likely candidate for reduced cognition in aged individuals for decades

[PubMed] [Google Scholar] Morrow A.L., Williams K., Sand A., Boanca G., Barycki J.J

As for the different sex-related activities of metabolizing enzymes, the specific activity of the catabolic enzyme gamma-glutamyltranspeptidase in female mice was 73% of that in male mice, suggesting that the faster glutathione turnover in males could account for the higher susceptibility to oxidative injury [64]

10.1016/j.jad.2020.12.143 79 ChiangJ

[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Lorzadeh N., Kazemirad Y., Kazemirad N