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doi: 10.1016/j.freeradbiomed.2021.02.040

Sustaining the engine: mitochondrial quality control and transport networks As the central engine of cellular bioenergetics and intermediary metabolism, mitochondrial functional integrity is critical for sustaining high metabolic flux, anabolic potential, and therapeutic responsiveness in CRC [18]

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Various regulators include genetic predispositions (including DNA repair deficiencies and IRF4 variants), peripheral clock genes, P-cadherin signaling, neuro-mediators, HGF, KIT ligand secretion, and impaired autophagic flux