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Vitamin B12 deficiency is most likely to develop in animals with reduced cobalamin absorption due to gastrointestinal disease and in dogs with pancreatic enzyme insufficiency (which is more common in certain breeds)

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Potential mechanisms include promoting access of soluble lipases to hydrophobic substrates, facilitating the formation of complexes between lipases and lipolysis-associated proteins, and stabilizing lipases at the surface of the lipid droplet
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