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Nutrients 10: 1-16

Further analysis revealed that AKT1 is also highly associated with key metabolic nodes, including adenine nucleotides (ATP, AMP), glutamic acid, and intermediates of the TCA cycle, suggesting a rewiring of the metabolic landscape toward increased energy demand, redox activity, and utilization of carbon and nitrogen substrates

120,127,149 Epigenetic silencing of ATGs (such as BECN1 and LC3 ) is frequently observed 33,38 but can be reversed by HDACis, thereby restoring proteostasis

J of Thorac & Cardiovasc Surg 151(4), 2016

Woods K, Steinman W, Bruns L et al

Furthermore, the active constituents were shown to reduce inflammatory responses and oxidative stress by inhibiting the release of inflammatory factors, blocking the NF-B signaling pathway, and suppressing TGF- expression