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Rotate sites weekly to prevent lipohypertrophy (fatty thickening) and avoid injecting into scars, moles, or irritated skin

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Synthetic control arms A statistical method used to estimate the outcomes of a treatment group in the absence of a traditional control group, wherein participants are not randomized to an active comparator or placebo, but data from such a group is constructed using either historical or external sources to closely resemble those undergoing treatment

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