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They can inhibit the expression of various cytokines, including IL-1, IL-2, and IL-6, and are commonly used in the treatment of inflammatory diseases of the digestive system ( 6.2.6 Indigo naturalis Indigo naturalis, derived from the plant Isatis tinctoria subsp

Centrifuged at 12,000 rpm for 30 min, and the supernatant was removed to acquired a pasty precipitation (NMP*)

To prompt cellular lysis, glass beads were added and the suspension was vortexed for 3 min

Control Release 350, 389400

Studies have indicated that HT thyroid tissues exhibit reduced GPX4 expression, leading to an imbalance in lipid peroxidation and antioxidant defenses, making thyroid cells highly susceptible to ferroptotic death (180, 181)

These data are protected by a confidentiality agreement with the study sponsor, Zambon S.p.A., Italy, due to their ethically and commercially sensitive nature