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Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial

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It also aligns with epidemiological observations that folate supplementation around conception reduces neural tube defectsa clear demonstration of gene-nutrient interaction in neurodevelopmentand invites inquiry into whether similar principles apply to ASD (though the ASD relationship is undoubtedly more complex and multifactorial)