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The high metabolic demands of malignant gliomas create a hypoxic tumor microenvironment (TME), triggering a shift in tissue metabolism towards glycolysis, which ultimately leads to elevated lactate levels [144]

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12 Potential adverse effects and risk considerations of probiotic supplementation 12.1 Historical safety record and regulatory frameworks For centuries, the consumption of fermented foods containing live microorganisms has been associated with human health benefits, providing a strong historical foundation for their safety