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This immunomodulatory effect was mediated through the inhibition of phosphorylation of key NF-B signaling components, including IKK, IKK, and IB (264)

Besides, as an FDA-approved immunomodulator, R848 is a hydrophobic imidazoquinoline-like molecule that can bind to toll-like receptors 7 and 8 (TLR7/8) and has already been applied in clinical trials for treating skin cancers 29

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The complete gene deletion of GSTM1 and the (GG) genotype of GSTP1 polymorphism (rs1695) have shown significant associations with breast cancer in South Indian 74 and Jordanian women

There is insufficient evidence to suggest that high-dose IV infusions are safe for a developing fetus
