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The SMAD proteins are categorized into three classes: the first class comprises receptor-regulated SMADs (R-Smads), which are downstream signaling molecules of the TGF- receptor complex and include mainly Smad1, Smad2, Smad3, Smad5, Smad8, and Smad9

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84 In a subsequent case series of patients with IBD and vitamin C deficiency, 16 (80%) of patients had symptoms consistent with clinical scurvy including arthralgias, rash, gingivitis, and brittle hair/nails and the majority of these patients (56%) reported fruit and vegetable avoidance

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Overview of Coronary Artery Disease