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Many patients experience mild or no side effects with proper titration and diet adjustments

Key secondary endpoints include change in waist circumference, blood pressure, lipid levels and patientreported health outcomes, as well as glycemic parameters in participants with T2D

[DOI] [PubMed] [Google Scholar] 103.Mann J.F., et al

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Boknik P, Grote-Wessels S, Barteska G, Jiang M, Mller FU, Schmitz W, Neumann J, Birnbaumer L (2009) Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium

Most weight-loss patients reach 1.7 to 2.4 mg weekly after 16 to 20 weeks of gradual increases, while some plateau at lower doses if they achieve their targets sooner