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However, due to its distinctive structure and function, disc presents unique characteristics: largely avascular, hypoxia, low pH, high osmotic pressure and high mechanical load 4,6,7

Similar content being viewed by others Introduction Obesity is a major chronic disease that continues to increase in prevalence worldwide and constitutes a key risk factor for development and progression of numerous related diseases including hypertension, dyslipidaemia and type 2 diabetes 1

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For example, despite differences in methodology, many types of cancers such as ovarian, breast, and lung, consistently display elevated levels of GSH [47]

I., Nature 2019, 576, 51

The non-heme iron-dependent enzymes can be divided into two sub-groups dependent upon whether the protein utilizes ferrous (Fe 2+ ) or ferric (Fe 3+ ) iron