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Clinical specimens exhibit marked metabolic protein dysregulation - PGC-1 expression decreases 65% compared to controls, concurrent with diminished UCP1 and Carnitine palmitoyltransferase 1 (CPT1) protein levels as determined by immunoblot analysis (88)

10.1126/science.1173288 Science 142 WangK.ZhangT.DongQ.NiceE

For the INTERMAP Research Group

Animal model studies provide further support for this mechanism

H.KimG.-Y.et al

Dietary supplements should not replace a varied diet
