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The association between osteoporosis and the decrease in cysteine was explained either by the reduced availability of cysteine for collagen formation or due to the increased use of cysteine by proteases in the osteoclastic hyperactivity that underlies the osteoporotic process [17]

Supplementation with both vitamin C and vitamin E improved the rate of wound healing in children with extensive burns [171], and plasma vitamin C levels in smokers, abstaining smokers and non-smokers were positively associated with the rate of wound healing [162]

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[DOI] [PubMed] [Google Scholar] 1541.Sarantis M, Everett K, Attwell D

It is also important to note that different conditions affect HbA1c in different ways: Haemolytic anaemia and acute blood loss shorten red cell lifespan and tend to lower HbA1c Iron deficiency anaemia is associated with increased HbA1c, likely due to prolonged red cell survival Haemoglobin variants (haemoglobinopathies) can cause variable or assay-dependent interference the effect depends on the specific variant and the HbA1c method used B12 or folate deficiency alters erythropoiesis and red cell indices, making HbA1c potentially unreliable in either direction Clinicians should therefore: Review the full blood count (FBC) alongside HbA1c Check serum B12 and folate when anaemia or macrocytosis (raised mean corpuscular volume, MCV) is identified Consider alternative glucose assessment methods specifically fasting plasma glucose or a 75 g OGTT for diagnostic purposes, or self-monitored blood glucose (SMBG) or fructosamine/glycated albumin for interim monitoring when HbA1c is unreliable Not sure where to start