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BMC Public Health 7 , 17 (2007)

Key functions of vitamin B12 include: Haematopoiesis supporting the production of healthy red blood cells and preventing megaloblastic anaemia Neurological function maintaining the myelin sheath that protects nerve fibres and supports cognitive function DNA synthesis facilitating cell division and growth throughout the body Metabolism working alongside folate to convert homocysteine to methionine, an amino acid important for protein synthesis Deficiency in vitamin B12 can lead to serious health consequences, including pernicious anaemia, peripheral neuropathy, cognitive impairment, and in severe cases, irreversible neurological damage

In a study of 10 healthy male volunteers, omeprazole, in doses of 20 mg-40 mg per day, caused a significant decrease in the oral absorption of methylcobalamin, vitamin B12

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These findings support further evaluation of thigh intramuscular injections in target populations, they concluded