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Since then, several antiangiogenic therapies, mainly targeting VEGF signaling pathway have been developed and approved for the treatment of a variety of tumors (Table 1)

Furthermore, one possible explanation for the pro-apoptotic effect of NF-B activation is that in the context of GPX1 deficiency, excess accumulation of cellular ROS might alter NF-B responses

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The secreted protein SP3 in PAVs of V991 is a 372-amino acid protein with a secretion signal peptide and predicted as a quercetinase (Supplementary Table 4)