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2.8.1 Basic science research Nigral iron deposition is demonstrated in in-vivo rat models of PD (Berg et al., 1999) and some evidences also show an alteration in iron metabolism in Zona Incerta, a brain region recently implicated in PD pathology in models of MPTP- and 6-OHDA-induced PD in mice (Xiu et al., 2025)

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