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Key phytochemicals including polyphenols (flavonoids, phenolic acids such as curcumin, resveratrol, and EGCG), carotenoids (lycopene, lutein), and organosulfur compounds demonstrate potent free radical scavenging capacity, regulate antioxidant enzyme activity, and inhibit lipid peroxidation through Nrf2 pathway activation and NF-B inhibition

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Remarkably, treating macaque iAstrocytes with human iAstrocyte-derived EVs leads to increased size and complexity of the macaque cells, highlighting a previously overlooked role of EVsand, evidently, the cargo they carryin brain evolution 45

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2018;115:E12228E34

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