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Similarly, the FDA-approved drug Ponatinib is a potent small-molecule PD-L1 inhibitor that binds strongly to PD-L1 and, in vivo , delays tumor growth more effectively than an anti-PD-L1 antibody, while enhancing T-Cell activity, offering a promising alternative to antibody-based therapy (73)

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Nevertheless, even among the classical studies on trauma, three studies focused on mtDNA (66, 67, 170), although the fourth study found that serum IL-6 levels, inflammation and critical illness correlated with the levels of nDNA, not mtDNA (68)

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