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In 1994, Yuet Kans lab discovered a powerful transcriptional activator of the CsMBE and the cellular REDOX responsea capncollar (CNC) protein they named NRF2 (also known as NFE2L2) [1]

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found that PDT treatment of colorectal cancer cells with a photosensitizer that specifically targets mitochondria induced elevated levels of mitochondrial ROS in the cells and induced colorectal cancer cells pyroptosis via the caspase 3/gasdermin E pathway

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In PDN mice model, IGF-1 expression in spinal microglia decreased significantly

10.18632/oncotarget.14412PubMed Abstract | CrossRef Full Text | Google Scholar 122 YangX.ZhuY.ShiQ.ZhaoX.HuangY.YaoF.et al (2021b)
