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One of the compounds most frequently described in this tradition is Epithalon a synthetic analogue of epithalamin, a peptide extract from the pineal gland (the gland responsible, among other things, for the rhythm of melatonin secretion)

Serious allergic reactions to this medicine are rare

Yet, the available preclinical data also report a favorable safety profile [4, 26, 27, 28]

Free radical biology & medicine

doi: 10.1038/s41419-018-0379-2 257 ShiY.LinS.StaatsK

By using the passive and/or active strategies for BBB regulation and crossing in a controlled and non-invasive manner, various drug delivery systems are engineered to facilitate the brain-targeted delivery of specific therapeutics including small-molecule drugs, proteins, genes, and other biopharmaceutics